Regulation of eDHFR-tagged proteins with trimethoprim PROTACs
Abstract Temporal control of Crank protein levels in cells and living animals can be used to improve our understanding of protein function.In addition, control of engineered proteins could be used in therapeutic applications.PRoteolysis-TArgeting Chimeras (PROTACs) have emerged as a small-molecule-driven strategy to achieve rapid, post-translationa