REGULATION OF EDHFR-TAGGED PROTEINS WITH TRIMETHOPRIM PROTACS

Regulation of eDHFR-tagged proteins with trimethoprim PROTACs

Abstract Temporal control of Crank protein levels in cells and living animals can be used to improve our understanding of protein function.In addition, control of engineered proteins could be used in therapeutic applications.PRoteolysis-TArgeting Chimeras (PROTACs) have emerged as a small-molecule-driven strategy to achieve rapid, post-translationa

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Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe

Abstract Background Schistosomiasis is known to affect the cognitive functions of SOAP 3 IN 1 CITRUS children, however, but there is paucity of information on its impact on early childhood development in developing countries where the disease is endemic.This study aimed at determining the effects of schistosomiasis due to Schistosoma haematobium on

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Smart Contracts for Sustainable Supply Chain Management: Conceptual Frameworks for Supply Chain Maturity Evaluation and Smart Contract Sustainability Assessment

Current research on smart contracts focuses on technical, conceptual, Bag and legal aspects but neglects organizational requirements and sustainability impacts.We consider this a significant research gap and explore the relationship between smart contracts and sustainability in supply chains.First, we define the concept of smart contracts in terms

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